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Pycnogenol Inhibits Enzymes Linked to Inflammation

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By: Sean Moloughney

Editor, Nutraceuticals World

Pycnogenol French maritime pine bark extract from Natural Health Science may reduce inflammation and sooth pain associated with various health problems, according to a recent study published in International Immunopharmacology.

The study involved healthy volunteers ages 35-50, who consumed Pycnogenol tablets (150 mg) for 5 consecutive days in the morning before breakfast. Blood was drawn before and after supplementation to investigate how immune cells respond toward pro-inflammatory stimuli. The behavior of specific white blood cells (leukocytes) for generating a repertoire of enzymes in inflammatory condition was tested by real-time PCR.

A baseline study revealed that the volunteers’ immune cells rapidly initiated production of COX-2, 5-LOX and FLAP enzymes upon pro-inflammatory stimulation. Taking Pycnogenol almost entirely subdued COX-2, 5-LOX and FLAP induction in the immune cells of volunteers. While Pycnogenol is not a COX-2-specific inhibitor, it blocks the COX-2 enzyme production during inflammation only. For further information: www.pycnogenol.com

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